PDK3 Antikörper

Produktnummer ABIN7256140

Produktdetails anti-PDK3 Antikörper

Target: PDK3 (Pyruvate Dehydrogenase Kinase, Isozyme 3 (PDK3))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PDK3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktmerkmale: Polyclonal Antibody

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein of human PDK3 (NP_005382.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu PDK3

Target: PDK3 (Pyruvate Dehydrogenase Kinase, Isozyme 3 (PDK3))

Andere Bezeichnung: PDK3 (PDK3 Produkte)

Synonyme: pdk3 antikoerper, PDK3 antikoerper, 2610001M10Rik antikoerper, AI035637 antikoerper, zgc:158702 antikoerper, pyruvate dehydrogenase kinase 3 antikoerper, pyruvate dehydrogenase kinase, isozyme 3a antikoerper, pyruvate dehydrogenase kinase, isoenzyme 3 antikoerper, fragile site, 5-azacytidine type, common, fra(1)(q12) antikoerper, pyruvate dehydrogenase kinase, isozyme 3b antikoerper, PDK3 antikoerper, Pdk3 antikoerper, pdk3a antikoerper, pdk3 antikoerper, FRA1J antikoerper, pdk3b antikoerper

Hintergrund: The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle, and thus is one of the major enzymes responsible for the regulation of glucose metabolism. The enzymatic activity of PDH is regulated by a phosphorylation/dephosphorylation cycle, and phosphorylation results in inactivation of PDH. The protein encoded by this gene is one of the three pyruvate dehydrogenase kinases that inhibits the PDH complex by phosphorylation of the E1 alpha subunit. This gene is predominantly expressed in the heart and skeletal muscles. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Molekulargewicht:

Observed_MW: 47 kDa

Calculated_MW: 46 kDa/48 kDa

Gen-ID: 5165

UniProt: Q15120

Pathways: PI3K-Akt Signalweg, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process, Warburg Effekt