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HLA-B Antikörper

HLA-B Reaktivität: Human, Maus, Ratte WB, IHC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN7256404
  • Target Alle HLA-B Antikörper anzeigen
    HLA-B (Major Histocompatibility Complex, Class I, B (HLA-B))
    Reaktivität
    • 96
    • 7
    • 7
    • 2
    Human, Maus, Ratte
    Wirt
    • 67
    • 26
    • 2
    • 1
    Kaninchen
    Klonalität
    • 72
    • 24
    Polyklonal
    Konjugat
    • 36
    • 16
    • 11
    • 9
    • 6
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser HLA-B Antikörper ist unkonjugiert
    Applikation
    • 55
    • 49
    • 28
    • 19
    • 16
    • 7
    • 2
    • 2
    • 2
    Western Blotting (WB), Immunohistochemistry (IHC)
    Produktmerkmale
    Polyclonal Antibody
    Aufreinigung
    Affinity purification
    Immunogen
    A synthetic peptide of human HLA-B (NP_005505.2).
    Isotyp
    IgG
    Top Product
    Discover our top product HLA-B Primärantikörper
  • Applikationshinweise
    WB 1:1000-1:2000 IHC 1:50-1:200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    HLA-B (Major Histocompatibility Complex, Class I, B (HLA-B))
    Andere Bezeichnung
    HLA-B (HLA-B Produkte)
    Synonyme
    AS antikoerper, HLAB antikoerper, SPDA1 antikoerper, mhc1b antikoerper, major histocompatibility complex, class I, B antikoerper, major histocompatibility complex nonclassical class Ib L homeolog antikoerper, HLA-B antikoerper, BOLA-B antikoerper, MAMU-B18 antikoerper, DKFZP469N1225 antikoerper, mhc1b.L antikoerper
    Hintergrund
    HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described.
    Molekulargewicht

    Observed_MW: 40 kDa

    Calculated_MW: 40 kDa

    Gen-ID
    3106
    UniProt
    P01889
    Pathways
    Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints, Human Leukocyte Antigen (HLA) in Adaptive Immune Response
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