RNF73 antikoerper, 2810024C04Rik antikoerper, Rad18sc antikoerper, zgc:55577 antikoerper, RAD18 antikoerper, DDBDRAFT_0218120 antikoerper, DDBDRAFT_0304878 antikoerper, DDB_0218120 antikoerper, DDB_0304878 antikoerper, DKFZp469H0810 antikoerper, RAD18, E3 ubiquitin protein ligase antikoerper, RAD18 E3 ubiquitin protein ligase antikoerper, E3 ubiquitin-protein ligase RAD18 antikoerper, E3 ubiquitin-protein ligase antikoerper, DNA repair protein and ATPase antikoerper, C3HC4-type zinc finger-containing protein antikoerper, RAD18 antikoerper, Rad18 antikoerper, rad18 antikoerper
Hintergrund
The protein encoded by this gene is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, this protein is able to interact with the human homolog of yeast Rad6 protein through a conserved ring-finger motif. Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens.