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PMS2 Antikörper

PMS2 Reaktivität: Human IF Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN7257297
  • Target Alle PMS2 Antikörper anzeigen
    PMS2 (PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2))
    Reaktivität
    • 58
    • 12
    • 8
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 44
    • 14
    Kaninchen
    Klonalität
    • 35
    • 23
    Polyklonal
    Konjugat
    • 41
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser PMS2 Antikörper ist unkonjugiert
    Applikation
    • 37
    • 26
    • 13
    • 12
    • 8
    • 6
    • 5
    • 3
    • 1
    • 1
    • 1
    • 1
    Immunofluorescence (IF)
    Produktmerkmale
    Polyclonal Antibody
    Aufreinigung
    Affinity purification
    Immunogen
    Recombinant fusion protein of human PMS2 (NP_000526.2).
    Isotyp
    IgG
    Top Product
    Discover our top product PMS2 Primärantikörper
  • Applikationshinweise
    IF 1:50-1:200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    PMS2 (PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2))
    Andere Bezeichnung
    PMS2 (PMS2 Produkte)
    Synonyme
    HNPCC4 antikoerper, PMS2CL antikoerper, PMSL2 antikoerper, AW555130 antikoerper, Pmsl2 antikoerper, PMS1 homolog 2, mismatch repair system component antikoerper, PMS1 homolog2, mismatch repair system component antikoerper, mismatch repair endonuclease PMS2 antikoerper, PMS2 antikoerper, Pms2 antikoerper, LOC463257 antikoerper, LOC107984056 antikoerper
    Hintergrund
    The protein encoded by this gene is a key component of the mismatch repair system that functions to correct DNA mismatches and small insertions and deletions that can occur during DNA replication and homologous recombination. This protein forms heterodimers with the gene product of the mutL homolog 1 (MLH1) gene to form the MutL-alpha heterodimer. The MutL-alpha heterodimer possesses an endonucleolytic activity that is activated following recognition of mismatches and insertion/deletion loops by the MutS-alpha and MutS-beta heterodimers, and is necessary for removal of the mismatched DNA. There is a DQHA(X)2E(X)4E motif found at the C-terminus of the protein encoded by this gene that forms part of the active site of the nuclease. Mutations in this gene have been associated with hereditary nonpolyposis colorectal cancer (HNPCC, also known as Lynch syndrome) and Turcot syndrome.
    Gen-ID
    5395
    UniProt
    P54278
    Pathways
    DNA Reparatur, Production of Molecular Mediator of Immune Response
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