Macrophage Scavenger Receptor 1 Antikörper

Produktnummer ABIN7257701

Produktdetails anti-Macrophage Scavenger Receptor 1 Antikörper

Target: Macrophage Scavenger Receptor 1 (MSR1)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Macrophage Scavenger Receptor 1 Antikörper ist unkonjugiert

Applikation: Immunofluorescence (IF)

Produktmerkmale: Polyclonal Antibody

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein of human MSR1 (NP_619729.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF 1:50-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu Macrophage Scavenger Receptor 1

Target: Macrophage Scavenger Receptor 1 (MSR1)

Andere Bezeichnung: MSR1 (MSR1 Produkte)

Synonyme: CD204 antikoerper, SCARA1 antikoerper, SR-A antikoerper, SRA antikoerper, phSR1 antikoerper, phSR2 antikoerper, MRS-A antikoerper, MSR antikoerper, MSR-A antikoerper, SR-AI antikoerper, SR-AII antikoerper, Scara1 antikoerper, Scvr antikoerper, MSR1 antikoerper, RGD1564316 antikoerper, macrophage scavenger receptor 1 antikoerper, scavenger receptor class A member 5 antikoerper, MSR1 antikoerper, Msr1 antikoerper, SCARA5 antikoerper

Hintergrund: This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages.

Gen-ID: 4481

UniProt: P21757