DKFZp459F101 antikoerper, AW060611 antikoerper, Mdc antikoerper, MDC antikoerper, mdc antikoerper, mdc11a antikoerper, xMDC11 antikoerper, ADAM metallopeptidase domain 11 antikoerper, a disintegrin and metallopeptidase domain 11 antikoerper, ADAM metallopeptidase domain 11 L homeolog antikoerper, ADAM11 antikoerper, adam11 antikoerper, Adam11 antikoerper, adam11.L antikoerper
Hintergrund
This gene encodes a member of the ADAM (a disintegrin and metalloprotease) protein family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. This gene represents a candidate tumor suppressor gene for human breast cancer based on its location within a minimal region of chromosome 17q21 previously defined by tumor deletion mapping. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.