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CDK5R1 Antikörper

CDK5R1 Reaktivität: Human, Maus, Ratte IF Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN7257908
  • Target Alle CDK5R1 Antikörper anzeigen
    CDK5R1 (Cyclin-Dependent Kinase 5, Regulatory Subunit 1 (p35) (CDK5R1))
    Reaktivität
    • 54
    • 47
    • 20
    • 12
    • 11
    • 10
    • 10
    • 5
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 51
    • 17
    • 1
    Kaninchen
    Klonalität
    • 45
    • 24
    Polyklonal
    Konjugat
    • 24
    • 6
    • 5
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser CDK5R1 Antikörper ist unkonjugiert
    Applikation
    • 55
    • 38
    • 34
    • 16
    • 14
    • 13
    • 13
    • 10
    • 7
    • 5
    • 5
    • 3
    • 1
    • 1
    Immunofluorescence (IF)
    Produktmerkmale
    Polyclonal Antibody
    Aufreinigung
    Affinity purification
    Immunogen
    Recombinant fusion protein of human CDK5R1 (NP_003876.1).
    Isotyp
    IgG
    Top Product
    Discover our top product CDK5R1 Primärantikörper
  • Applikationshinweise
    IF 1:50-1:200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    CDK5R1 (Cyclin-Dependent Kinase 5, Regulatory Subunit 1 (p35) (CDK5R1))
    Andere Bezeichnung
    CDK5R1 (CDK5R1 Produkte)
    Synonyme
    CDK5P35 antikoerper, CDK5R antikoerper, NCK5A antikoerper, p23 antikoerper, p25 antikoerper, p35 antikoerper, p35nck5a antikoerper, cdk5r1 antikoerper, zgc:92814 antikoerper, CDK5R1 antikoerper, Cdk5r antikoerper, P25/P35 antikoerper, D11Bwg0379e antikoerper, Xp35.1 antikoerper, cyclin dependent kinase 5 regulatory subunit 1 antikoerper, cyclin-dependent kinase 5, regulatory subunit 1b (p35) antikoerper, cyclin-dependent kinase 5 regulatory subunit 1 antikoerper, S100 calcium binding protein A9 antikoerper, cyclin-dependent kinase 5, regulatory subunit 1 (p35) antikoerper, cyclin-dependent kinase 5, regulatory subunit 1 (p35) L homeolog antikoerper, CDK5R1 antikoerper, cdk5r1b antikoerper, Cdk5r1 antikoerper, S100A9 antikoerper, cdk5r1.L antikoerper
    Substanzklasse
    Viral Protein
    Hintergrund
    The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5), the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease.
    Gen-ID
    8851
    UniProt
    Q15078
    Pathways
    Stem Cell Maintenance, Regulation of Cell Size, Positive Regulation of Endopeptidase Activity
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