ZCCHC3 Antikörper
-
- Target Alle ZCCHC3 Produkte
- ZCCHC3 (Zinc Finger, C3HC-Type Containing 3 (ZCCHC3))
-
Reaktivität
- Human, Maus
-
Wirt
- Kaninchen
-
Klonalität
- Polyklonal
-
Konjugat
- Dieser ZCCHC3 Antikörper ist unkonjugiert
-
Applikation
- Immunofluorescence (IF)
- Produktmerkmale
- Polyclonal Antibody
- Aufreinigung
- Affinity purification
- Immunogen
- Recombinant fusion protein of human ZCCHC3 (NP_149080.2).
- Isotyp
- IgG
-
-
- Applikationshinweise
- IF 1:50-1:200
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C. Avoid freeze / thaw cycles.
-
- Target
- ZCCHC3 (Zinc Finger, C3HC-Type Containing 3 (ZCCHC3))
- Andere Bezeichnung
- ZCCHC3 (ZCCHC3 Produkte)
- Synonyme
- C20orf99 antikoerper, 2810406K24Rik antikoerper, zinc finger CCHC-type containing 3 antikoerper, zinc finger, CCHC domain containing 3 antikoerper, ZCCHC3 antikoerper, Zcchc3 antikoerper
- Hintergrund
- Nucleic acid-binding protein involved in innate immune response to DNA and RNA viruses (PubMed:30193849, PubMed:30135424). Binds DNA and RNA in the cytoplasm and acts by promoting recognition of viral nucleic acids by virus sensors, such as DDX58/RIG-I, IFIH1/MDA5 and CGAS (PubMed:30193849, PubMed:30135424). Acts as a co-sensor for recognition of double-stranded DNA (dsDNA) by cGAS in the cytoplasm, thereby playing a role in innate immune response to cytosolic dsDNA and DNA virus (PubMed:30135424). Binds dsDNA and probably acts by promoting sensing of dsDNA by CGAS, leading to enhance CGAS oligomerization and activation (PubMed:30135424). Promotes sensing of viral RNA by RIG-I-like receptors proteins DDX58/RIG-I and IFIH1/MDA5 via two mechanisms: binds double-stranded RNA (dsRNA), enhancing the binding of DDX58/RIG-I and IFIH1/MDA5 to dsRNA and promotes 'Lys-63'-linked ubiquitination and subsequent activation of DDX58/RIG-I and IFIH1/MDA5.
- Gen-ID
- 85364
- UniProt
- Q9NUD5
-