NUAK1 Antikörper
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- Target Alle NUAK1 Antikörper anzeigen
- NUAK1 (NUAK Family, SNF1-Like Kinase, 1 (NUAK1))
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Reaktivität
- Human, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser NUAK1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Produktmerkmale
- Polyclonal Antibody
- Aufreinigung
- Affinity purification
- Immunogen
- Recombinant fusion protein of human NUAK1 (NP_055655.1).
- Isotyp
- IgG
- Top Product
- Discover our top product NUAK1 Primärantikörper
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- Applikationshinweise
- WB 1:200-1:2000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C. Avoid freeze / thaw cycles.
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- Target
- NUAK1 (NUAK Family, SNF1-Like Kinase, 1 (NUAK1))
- Andere Bezeichnung
- NUAK1 (NUAK1 Produkte)
- Synonyme
- ARK5 antikoerper, AU014801 antikoerper, AW494241 antikoerper, B230104P22Rik antikoerper, Omphk1 antikoerper, NUAK family kinase 1 antikoerper, NUAK family, SNF1-like kinase, 1 antikoerper, NUAK1 antikoerper, Nuak1 antikoerper
- Hintergrund
- NUAK family SNF1-like kinase 1also known asAMPK-related protein kinase 5(ARK5) is anenzymethat in humans is encoded by theNUAK1gene. Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1: phosphorylated PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1.
- Molekulargewicht
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Observed_MW: 74 kDa
Calculated_MW: 23 kDa/74 kDa
- Gen-ID
- 9891
- UniProt
- O60285
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