PSMC2 Antikörper

Produktnummer ABIN7260033

Produktdetails anti-PSMC2 Antikörper

Target: PSMC2 (Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 2 (PSMC2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PSMC2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktmerkmale: Polyclonal Antibody

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein of human PSMC2 (NP_002794.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000 IHC 1:50-1:200 IF 1:50-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu PSMC2

Target: PSMC2 (Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 2 (PSMC2))

Andere Bezeichnung: PSMC2 (PSMC2 Produkte)

Synonyme: xMSS1 antikoerper, psmc2 antikoerper, DDBDRAFT_0168337 antikoerper, DDBDRAFT_0232966 antikoerper, DDB_0168337 antikoerper, DDB_0232966 antikoerper, MSS1 antikoerper, Nbla10058 antikoerper, S7 antikoerper, NCU02840.1 antikoerper, zgc:63995 antikoerper, proteasome 26S subunit, ATPase 2 L homeolog antikoerper, proteasome (prosome, macropain) 26S subunit, ATPase 2 antikoerper, 26S protease regulatory subunit 7 antikoerper, proteasome 26S subunit, ATPase 2 antikoerper, regulatory particle, ATPase-like-1 antikoerper, psmc2.L antikoerper, psmc2 antikoerper, psmC2 antikoerper, PSMC2 antikoerper, rpt-1 antikoerper, GL50803_21331 antikoerper, EHI_080890 antikoerper, UREG_01412 antikoerper, PITG_10169 antikoerper, Psmc2 antikoerper, GL50803_86683 antikoerper, Tsp_09237 antikoerper

Hintergrund: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit has been shown to interact with several of the basal transcription factors so, in addition to participation in proteasome functions, this subunit may participate in the regulation of transcription. This subunit may also compete with PSMC3 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Molekulargewicht:

Observed_MW: 49 kDa

Calculated_MW: 33 kDa/48 kDa

Gen-ID: 5701

UniProt: P35998

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA, Ubiquitin Proteasome Pathway