Deoxyuridine Triphosphatase (DUT) Antikörper

Produktnummer ABIN7260715

Produktdetails

Target: Deoxyuridine Triphosphatase (DUT)

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktmerkmale: Polyclonal Antibody

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein of human DUT (NP_001020419.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:1000 IHC 1:50-1:200 IF 1:100-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Antigendetails

Target: Deoxyuridine Triphosphatase (DUT)

Andere Bezeichnung: DUT (DUT Produkte)

Synonyme: BcDNA:LD08534 antikoerper, CG4584 antikoerper, Dmel\\CG4584 antikoerper, LD08534 antikoerper, UTPase antikoerper, anon-SAGE:Wang-077 antikoerper, dUTPase antikoerper, Tb07.27E10.390 antikoerper, dutpase antikoerper, 5031412I06Rik antikoerper, 5133400F09Rik antikoerper, D2Bwg0749e antikoerper, Dutp antikoerper, PIP4 antikoerper, deoxyuridine triphosphatase antikoerper, Deoxyuridine triphosphatase antikoerper, dUTPase; ORF54; similar to EBV BLLF3, CMV UL72, HSV UL50 antikoerper, involved in nucleotide metabolism antikoerper, tegument protein antikoerper, dUTPase antikoerper, deoxyuridine triphosphatase L homeolog antikoerper, DUT antikoerper, dUTPase antikoerper, P18 antikoerper, AlHV1gp51 antikoerper, UL50 antikoerper, HVT058 antikoerper, ORF9 antikoerper, ORF8 antikoerper, U45 antikoerper, GAMMAHV.ORF54 antikoerper, Tc00.1047053509151.130 antikoerper, Tc00.1047053508175.160 antikoerper, Tb927.7.5160 antikoerper, dut.L antikoerper, Dut antikoerper

Substanzklasse: Viral Protein

Hintergrund: This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19.

Molekulargewicht:

Observed_MW: 24 kDa

Calculated_MW: 17 kDa/26 kDa

Gen-ID: 1854

UniProt: P33316