GTF2H2 Antikörper

Produktnummer ABIN7261267

Produktdetails anti-GTF2H2 Antikörper

Target: GTF2H2 (General Transcription Factor IIH, Polypeptide 2, 44kDa (GTF2H2))

Reaktivität: Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GTF2H2 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Produktmerkmale: Polyclonal Antibody

Aufreinigung: Affinity purification

Immunogen: A synthetic peptide of human GTF2H2 (NP_001506.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC 1:50-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu GTF2H2

Target: GTF2H2 (General Transcription Factor IIH, Polypeptide 2, 44kDa (GTF2H2))

Andere Bezeichnung: GTF2H2 (GTF2H2 Produkte)

Synonyme: 44kDa antikoerper, BTF2 p44 antikoerper, BTF2-p44 antikoerper, Btf2p44 antikoerper, p44 antikoerper, BTF2 antikoerper, BTF2P44 antikoerper, T-BTF2P44 antikoerper, TFIIH antikoerper, general transcription factor II H, polypeptide 2 antikoerper, general transcription factor IIH subunit 2 antikoerper, general transcription factor IIH, polypeptide 2, 44kDa antikoerper, Gtf2h2 antikoerper, GTF2H2 antikoerper

Hintergrund: This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. This gene is within the telomeric copy of the duplication. Deletion of this gene sometimes accompanies deletion of the neighboring SMN1 gene in spinal muscular atrophy (SMA) patients but it is unclear if deletion of this gene contributes to the SMA phenotype. This gene encodes the 44 kDa subunit of RNA polymerase II transcription initiation factor IIH which is involved in basal transcription and nucleotide excision repair. Transcript variants for this gene have been described, but their full length nature has not been determined. A second copy of this gene within the centromeric copy of the duplication has been described in the literature. It is reported to be different by either two or four base pairs, however, no sequence data is currently available for the centromeric copy of the gene.

Gen-ID: 2966

UniProt: Q13888

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling