HUS1 Antikörper

Produktnummer ABIN7261357

Produktdetails anti-HUS1 Antikörper

Target: HUS1 (HUS1 Checkpoint Homolog (S. Pombe) (HUS1))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HUS1 Antikörper ist unkonjugiert

Applikation: Immunofluorescence (IF)

Produktmerkmale: Polyclonal Antibody

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein of human HUS1 (NP_004498.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF 1:50-1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu HUS1

Target: HUS1 (HUS1 Checkpoint Homolog (S. Pombe) (HUS1))

Andere Bezeichnung: HUS1 (HUS1 Produkte)

Synonyme: hHUS1 antikoerper, mHus1 antikoerper, XHus1 antikoerper, hus1 antikoerper, HUS1 checkpoint clamp component antikoerper, checkpoint clamp complex protein Hus1 antikoerper, HUS1 checkpoint clamp component L homeolog antikoerper, HUS1 antikoerper, Hus1 antikoerper, hus1 antikoerper, hus1.L antikoerper

Hintergrund: The protein encoded by this gene is a component of an evolutionarily conserved, genotoxin-activated checkpoint complex that is involved in the cell cycle arrest in response to DNA damage. This protein forms a heterotrimeric complex with checkpoint proteins RAD9 and RAD1. In response to DNA damage, the trimeric complex interacts with another protein complex consisting of checkpoint protein RAD17 and four small subunits of the replication factor C (RFC), which loads the combined complex onto the chromatin. The DNA damage induced chromatin binding has been shown to depend on the activation of the checkpoint kinase ATM, and is thought to be an early checkpoint signaling event. Alternative splicing results in multiple transcript variants.

Gen-ID: 3364

UniProt: O60921