CLOCK Antikörper

Produktnummer ABIN7261578

Produktdetails anti-CLOCK Antikörper

Target: CLOCK (Clock Homolog (Mouse) (CLOCK))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CLOCK Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktmerkmale: Polyclonal Antibody

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein of human CLOCK (NP_004889.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu CLOCK

Target: CLOCK (Clock Homolog (Mouse) (CLOCK))

Andere Bezeichnung: CLOCK (CLOCK Produkte)

Synonyme: CG7391 antikoerper, CLK antikoerper, CLOCK antikoerper, Dmel\\CG7391 antikoerper, Jerk antikoerper, Jrk antikoerper, PAS1 antikoerper, bHLHe10 antikoerper, clk antikoerper, clock antikoerper, dCLK antikoerper, dCLK/JRK antikoerper, dCLOCK antikoerper, dClck antikoerper, dClk antikoerper, dClock antikoerper, dclk antikoerper, jrk antikoerper, Xclk antikoerper, XClock antikoerper, zCLOCK1 antikoerper, zfCLOCK1 antikoerper, 5330400M04Rik antikoerper, KAT13D antikoerper, bHLHe8 antikoerper, mKIAA0334 antikoerper, Clock antikoerper, clock circadian regulator antikoerper, clock homolog (mouse) antikoerper, clock circadian regulator a antikoerper, circadian locomotor output cycles kaput antikoerper, clock circadian regulator L homeolog antikoerper, Clk antikoerper, CLOCK antikoerper, clock antikoerper, clocka antikoerper, Clock antikoerper, clock.L antikoerper

Hintergrund: The protein encoded by this gene plays a central role in the regulation of circadian rhythms. The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and contains DNA binding histone acetyltransferase activity. The encoded protein forms a heterodimer with ARNTL (BMAL1) that binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Polymorphisms in this gene may be associated with behavioral changes in certain populations and with obesity and metabolic syndrome. Alternative splicing results in multiple transcript variants.

Molekulargewicht:

Observed_MW: 110 kDa

Calculated_MW: 95 kDa

Gen-ID: 9575

UniProt: O15516

Pathways: Regulation of Lipid Metabolism by PPARalpha, Photoperiodism