IREB2 Antikörper

Produktnummer ABIN7262188

Produktdetails anti-IREB2 Antikörper

Target: IREB2 (Iron-Responsive Element Binding Protein 2 (IREB2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IREB2 Antikörper ist unkonjugiert

Applikation: Immunofluorescence (IF)

Produktmerkmale: Polyclonal Antibody

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein of human IREB2 (NP_004127.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF 1:20-1:50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu IREB2

Target: IREB2 (Iron-Responsive Element Binding Protein 2 (IREB2))

Andere Bezeichnung: IREB2 (IREB2 Produkte)

Synonyme: IREB2 antikoerper, im:7153062 antikoerper, DKFZp468N047 antikoerper, D9Ertd85e antikoerper, Irp2 antikoerper, ACO3 antikoerper, IRP2 antikoerper, IRP2AD antikoerper, IREBP2 antikoerper, iron responsive element binding protein 2 antikoerper, iron-responsive element binding protein 2 antikoerper, iron responsive element binding protein 2 L homeolog antikoerper, IREB2 antikoerper, ireb2 antikoerper, Ireb2 antikoerper, ireb2.L antikoerper

Hintergrund: The protein encoded by this gene is an RNA-binding protein that acts to regulate iron levels in the cells by regulating the translation and stability of mRNAs that affect iron homeostasis under conditions when iron is depleted. When iron levels are low, this protein binds to iron-responsive elements (IRES), stem-loop structures located either in the 5' or 3' UTRs. Binding to the 5' UTR represses translation, while binding to the 3' UTR inhibits mRNA degradation. When iron is found in the cell, this protein is degraded in a F-box and leucine rich repeat protein 5-dependent manner. Variants in this gene have been associated with lung cancer and chronic obstructive pulmonary disease (COPD). Alternative splicing results in multiple transcript variants encoding different isoforms.

Gen-ID: 3658

UniProt: P48200

Pathways: Transition Metal Ion Homeostasis