COCH Antikörper
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- Target Alle COCH Antikörper anzeigen
- COCH (Cochlin (COCH))
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser COCH Antikörper ist unkonjugiert
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Applikation
- Immunohistochemistry (IHC), Immunofluorescence (IF)
- Produktmerkmale
- Polyclonal Antibody
- Aufreinigung
- Affinity purification
- Immunogen
- Recombinant fusion protein of human COCH (NP_001128530.1).
- Isotyp
- IgG
- Top Product
- Discover our top product COCH Primärantikörper
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- Applikationshinweise
- IHC 1:50-1:100 IF 1:50-1:100
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C. Avoid freeze / thaw cycles.
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- Target
- COCH (Cochlin (COCH))
- Andere Bezeichnung
- COCH (COCH Produkte)
- Synonyme
- AW122937 antikoerper, Coch-5B2 antikoerper, D12H14S564E antikoerper, COCH-5B2 antikoerper, COCH5B2 antikoerper, DFNA9 antikoerper, cochlin antikoerper, Coch antikoerper, COCH antikoerper
- Hintergrund
- The protein encoded by this gene is highly conserved in human, mouse, and chicken, showing 94 % and 79 % amino acid identity of human to mouse and chicken sequences, respectively. Hybridization to this gene was detected in spindle-shaped cells located along nerve fibers between the auditory ganglion and sensory epithelium. These cells accompany neurites at the habenula perforata, the opening through which neurites extend to innervate hair cells. This and the pattern of expression of this gene in chicken inner ear paralleled the histologic findings of acidophilic deposits, consistent with mucopolysaccharide ground substance, in temporal bones from DFNA9 (autosomal dominant nonsyndromic sensorineural deafness 9) patients. Mutations that cause DFNA9 have been reported in this gene. Alternative splicing results in multiple transcript variants encoding the same protein. Additional splice variants encoding distinct isoforms have been described but their biological validities have not been demonstrated.
- Gen-ID
- 1690
- UniProt
- O43405
- Pathways
- Sensory Perception of Sound
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