EIF3C Antikörper

Produktnummer ABIN7262965

Produktdetails anti-EIF3C Antikörper

Target: EIF3C (Eukaryotic Translation Initiation Factor 3 Subunit C (EIF3C))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EIF3C Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktmerkmale: Polyclonal Antibody

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein of human EIF3C (NP_003743.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC 1:50-1:200 IF 1:50-1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu EIF3C

Target: EIF3C (Eukaryotic Translation Initiation Factor 3 Subunit C (EIF3C))

Andere Bezeichnung: EIF3C (EIF3C Produkte)

Synonyme: eif3s8 antikoerper, fi37c04 antikoerper, zgc:66128 antikoerper, wu:fb34a08 antikoerper, wu:fi37c04 antikoerper, EIF3S8 antikoerper, EIF3CL antikoerper, eif3-p110 antikoerper, LOC733086 antikoerper, eIF3c antikoerper, eIF3-S8 antikoerper, AO090011000340 antikoerper, eIF3-p110 antikoerper, 110kDa antikoerper, 3230401O13Rik antikoerper, Eif3s8 antikoerper, NIPIL(A3) antikoerper, NipilA3 antikoerper, Xs antikoerper, Xsl antikoerper, EIF3C antikoerper, eukaryotic translation initiation factor 3, subunit C antikoerper, eukaryotic translation initiation factor 3 subunit C antikoerper, eukaryotic translation initiation factor 3 subunit 8 antikoerper, Eukaryotic translation initiation factor 3 subunit C antikoerper, translation initiation factor eIF3c antikoerper, translation initiation factor eIF-3 subunit 8 antikoerper, eukaryotic translation initiation factor 3 subunit C L homeolog antikoerper, eukaryotic translation initiation factor 3, subunit C-like antikoerper, eif3c antikoerper, LOC454016 antikoerper, LOC479795 antikoerper, EIF3C antikoerper, Smp_000480 antikoerper, eIF3c antikoerper, ANI_1_1094124 antikoerper, AOR_1_578054 antikoerper, PTRG_08272 antikoerper, SJAG_04981 antikoerper, TERG_03202 antikoerper, PGTG_09255 antikoerper, Tsp_05110 antikoerper, Eif3c antikoerper, eif3c.L antikoerper, EIF3CL antikoerper, eif-3.C antikoerper

Hintergrund: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).

Gen-ID: 8663

UniProt: Q99613

Pathways: Ribonucleoprotein Complex Subunit Organization