TEK antikoerper, DKFZp469E064 antikoerper, AA517024 antikoerper, Cd202b antikoerper, Hyk antikoerper, Tie2 antikoerper, tie-2 antikoerper, CD202B antikoerper, TIE-2 antikoerper, TIE2 antikoerper, VMCM antikoerper, VMCM1 antikoerper, Tie-2 antikoerper, tie2 antikoerper, TEK receptor tyrosine kinase antikoerper, angiopoietin-1 receptor antikoerper, TEK tyrosine kinase, endothelial antikoerper, TEK antikoerper, LOC100408334 antikoerper, tek antikoerper, Tek antikoerper
Hintergrund
This gene encodes a receptor that belongs to the protein tyrosine kinase Tie2 family. The encoded protein possesses a unique extracellular region that contains two immunoglobulin-like domains, three epidermal growth factor (EGF)-like domains and three fibronectin type III repeats. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Mutations in this gene are associated with inherited venous malformations of the skin and mucous membranes. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.