OAZ1 Antikörper

Produktnummer ABIN7263455

Produktdetails anti-OAZ1 Antikörper

Target: OAZ1 (Ornithine Decarboxylase Antizyme 1 (OAZ1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser OAZ1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Produktmerkmale: Polyclonal Antibody

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein of human OAZ1 (NP_004143.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC 1:50-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu OAZ1

Target: OAZ1 (Ornithine Decarboxylase Antizyme 1 (OAZ1))

Andere Bezeichnung: OAZ1 (OAZ1 Produkte)

Synonyme: AZI antikoerper, OAZ antikoerper, AZ-1 antikoerper, AZ1 antikoerper, Antizyme antikoerper, ODC-Az antikoerper, Oaz antikoerper, ODCAC antikoerper, oaz antikoerper, AZS antikoerper, oaz1 antikoerper, ornithine decarboxylase antizyme 1 antikoerper, ornithine decarboxylase antizyme 1 S homeolog antikoerper, ornithine decarboxylase antizyme 1a antikoerper, OAZ1 antikoerper, Oaz1 antikoerper, oaz1.S antikoerper, oaz1a antikoerper

Hintergrund: The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis, thus, completing the auto-regulatory circuit. This gene encodes antizyme 1, the first member of the antizyme family, that has broad tissue distribution, and negatively regulates intracellular polyamine levels by binding to and targeting ODC for degradation, as well as inhibiting polyamine uptake. Antizyme 1 mRNA contains two potential in-frame AUGs, and studies in rat suggest that alternative use of the two translation initiation sites results in N-terminally distinct protein isoforms with different subcellular localization. Alternatively spliced transcript variants have also been noted for this gene.

Gen-ID: 4946

UniProt: P54368