CRTC1 Antikörper (Biotin)

Produktnummer ABIN701232

Produktdetails anti-CRTC1 Antikörper (Biotin)

Target: CRTC1 (CREB Regulated Transcription Coactivator 1 (CRTC1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CRTC1 Antikörper ist konjugiert mit Biotin

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human TORC1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:100-1000, IHC-P: 1:100-500
Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu CRTC1

Target: CRTC1 (CREB Regulated Transcription Coactivator 1 (CRTC1))

Andere Bezeichnung: Torc1/Crtc1 (CRTC1 Produkte)

Synonyme: MECT1 antikoerper, TORC-1 antikoerper, TORC1 antikoerper, WAMTP1 antikoerper, AI413414 antikoerper, Mect1 antikoerper, R74955 antikoerper, mKIAA0616 antikoerper, CRTC1 antikoerper, crtc1 antikoerper, fc68c05 antikoerper, pde4cb antikoerper, si:ch211-255d18.1 antikoerper, si:ch211-255d18.8 antikoerper, wu:fc68c05 antikoerper, CREB regulated transcription coactivator 1 antikoerper, CREB regulated transcription coactivator 1b antikoerper, CRTC1 antikoerper, Crtc1 antikoerper, crtc1 antikoerper, crtc1b antikoerper

Hintergrund:

Synonyms: CREB regulated transcription coactivator 1, CRTC1, KIAA0616, MECT 1, Mucoepidermoid carcinoma translocated protein 1, also known as MucoEpidermoid Carcinoma Translocated 1, TORC1, Transducer of CREB protein 1, Transducer of regulated cAMP response element binding protein 1, WAMTP1.

Background: which activates transcription through both consensus and variant cAMP response element (CRE) sites. MECT1 does not appear to modulate CREB1 DNA-binding activity but enhances the interaction of CREB1 with TAF4/TAFII-130. MECT1 translocates with MAML2 (MasterMind-Like Protein 2) to yield a fusion oncogene: t(11,19) (q21,p13). This translocation occurs in mucoepidermoid carcinomas, benign Warthin tumors and clear cell hidradenomas. The novel fusion product that results disrupts the Notch signaling pathway. The fusion protein consists of the N-terminus of MECT1 joined to the C-terminus of MAML2. The reciprocal fusion protein consisting of the N-terminus of MAML2 joined to the C-terminus of MECT1 has been detected in a small number of mucoepidermoid carcinomas. Multiple isoforms have been reported for the MECT1 protein.

Gen-ID: 23373