PER antikoerper, RIGUI antikoerper, hPER antikoerper, per1 antikoerper, si:ch211-237l4.4 antikoerper, Per antikoerper, m-rigui antikoerper, mPer1 antikoerper, rper1 antikoerper, Rigui-like antikoerper, per4 antikoerper, zfper4 antikoerper, period circadian regulator 1 antikoerper, period circadian clock 1a antikoerper, period circadian clock 1 antikoerper, period homolog 1 (Drosophila) antikoerper, period circadian clock 1b antikoerper, PER1 antikoerper, per1a antikoerper, per1 antikoerper, Per1 antikoerper, per1b antikoerper
Hintergrund
This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene may increase the risk of getting certain cancers. Alternative splicing has been observed in this gene, however, these variants have not been fully described.