-
- Target Alle STRA13 Antikörper anzeigen
- STRA13 (Stimulated By Retinoic Acid 13 Homolog (STRA13))
- Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser STRA13 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Produktmerkmale
- Polyclonal Antibody
- Aufreinigung
- Affinity purification
- Immunogen
- Recombinant fusion protein of human STRA13 (NP_659435.2).
- Isotyp
- IgG
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anti-Stimulated By Retinoic Acid 13 Homolog (STRA13) (N-Term) antibody
STRA13 Reaktivität: Human WB Wirt: Kaninchen Polyclonal unconjugated
anti-Stimulated By Retinoic Acid 13 Homolog (STRA13) (AA 1-63) antibodySTRA13 Reaktivität: Human WB Wirt: Kaninchen Polyclonal unconjugated
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- Applikationshinweise
- WB 1:500-1:2000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C. Avoid freeze / thaw cycles.
-
- Target
- STRA13 (Stimulated By Retinoic Acid 13 Homolog (STRA13))
- Andere Bezeichnung
- STRA13 (STRA13 Produkte)
- Synonyme
- CENP-X antikoerper, CENPX antikoerper, D9 antikoerper, FAAP10 antikoerper, MHF2 antikoerper, BHLHB2 antikoerper, centromere protein X antikoerper, CENPX antikoerper, Cenpx antikoerper
- Hintergrund
- DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM. In complex with CENPS and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked replication forks (PubMed:20347428, PubMed:20347429). In complex with CENPS, CENPT and CENPW (CENP-T-W-S-X heterotetramer), involved in the formation of a functional kinetochore outer plate, which is essential for kinetochore-microtubule attachment and faithful mitotic progression. As a component of MHF and CENP-T-W-S-X complexes, binds DNA and bends it to form a nucleosome-like structure.
- Molekulargewicht
-
Observed_MW: 14 kDa
Calculated_MW: 6 kDa/7 kDa/8 kDa
- Gen-ID
- 201254
- UniProt
- A8MT69
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