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Phospholamban Antikörper (pThr17)

PLN Reaktivität: Human, Ratte, Maus IHC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN7265288
  • Target Alle Phospholamban (PLN) Antikörper anzeigen
    Phospholamban (PLN)
    Bindungsspezifität
    • 30
    • 18
    • 17
    • 9
    • 8
    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    pThr17
    Reaktivität
    • 83
    • 25
    • 24
    • 3
    • 2
    • 2
    • 2
    Human, Ratte, Maus
    Wirt
    • 83
    • 1
    • 1
    Kaninchen
    Klonalität
    • 85
    Polyklonal
    Konjugat
    • 32
    • 6
    • 6
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Phospholamban Antikörper ist unkonjugiert
    Applikation
    • 34
    • 26
    • 26
    • 24
    • 12
    • 9
    • 9
    • 8
    • 7
    • 6
    • 5
    • 4
    • 1
    • 1
    Immunohistochemistry (IHC)
    Produktmerkmale
    Phosphorylated antibody
    Aufreinigung
    Affinity purification
    Immunogen
    A phospho specific peptide corresponding to residues surrounding T17 of human PLN
    Isotyp
    IgG
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  • Applikationshinweise
    IHC 1:50-1:200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    Phospholamban (PLN)
    Andere Bezeichnung
    PLN (PLN Produkte)
    Synonyme
    LOC100226261 antikoerper, plb antikoerper, cmd1p antikoerper, CMD1P antikoerper, CMH18 antikoerper, PLB antikoerper, Plb antikoerper, Plm antikoerper, phospholamban antikoerper, PLN antikoerper, pln antikoerper, Pln antikoerper
    Hintergrund
    The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure, and also familial hypertrophic cardiomyopathy.
    Gen-ID
    5350
    UniProt
    P26678
    Pathways
    Negative Regulation of Transporter Activity
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