CAB39 Antikörper (AA 201-300)

Produktnummer ABIN701905

Produktdetails anti-CAB39 Antikörper

Target: CAB39 (Calcium Binding Protein 39 (CAB39))

Bindungsspezifität: AA 201-300

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CAB39 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Homologie: Human,Mouse,Rat,Dog,Cow,Pig,Horse,Chicken,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human MO25 alpha/CAB39

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu CAB39

Target: CAB39 (Calcium Binding Protein 39 (CAB39))

Andere Bezeichnung: MO25 alpha/CAB39 (CAB39 Produkte)

Synonyme: CG4083 antikoerper, Dmel\\CG4083 antikoerper, Dmo25 antikoerper, dMo25 antikoerper, l(3)00274 antikoerper, mo25 antikoerper, fc06a03 antikoerper, zgc:86716 antikoerper, wu:fc06a03 antikoerper, MGC78903 antikoerper, CAB39 antikoerper, MO25 antikoerper, AA408805 antikoerper, AA960512 antikoerper, C78372 antikoerper, MO25alpha antikoerper, CG4083 gene product from transcript CG4083-RA antikoerper, calcium binding protein 39 antikoerper, calcium binding protein 39 L homeolog antikoerper, Cab39 protein antikoerper, Mo25 antikoerper, cab39 antikoerper, cab39.L antikoerper, CAB39 antikoerper, Bm1_33380 antikoerper, Cab39 antikoerper

Hintergrund:

Synonyms: CAB39, Calcium binding protein 39, CGI 66, CGI66, MO25 alpha, MO25, Mouse protein 25 alpha, Protein Mo25.

Background: Mouse protein 25 alpha (MO25 alpha, CAB39) is a 40- kDa protein that, together with the STE20-related adaptor-alpha (STRAD alpha) pseudo kinase, forms a regulatory complex capable of stimulating the activity of the LKB1 tumor suppressor protein kinase. The latter is mutated in the inherited Peutz-Jeghers cancer syndrome (PJS). CAB39 binds directly to a conserved Trp-Glu-Phe sequence at the STRAD alpha C terminus, markedly enhancing binding of STRAD alpha to LKB1 and increasing LKB1 catalytic activity. Skeletal muscle contraction results in the phosphorylation and activation of the AMP-activated protein kinase (AMPK) by an upstream kinase (AMPKK). The LKB1-STE-related adaptor (STRAD)-mouse protein 25 (MO25) complex is the major AMPKK in skeletal muscle, however, LKB1-STRAD-MO25 activity is not increased by muscle contraction. This relationship suggests that phosphorylation of AMPK by LKB1-STRAD-MO25 during skeletal muscle contraction may be regulated by allosteric mechanisms.

Gen-ID: 51719

Pathways: AMPK Signaling