APC Antikörper (AA 2751-2843)

Produktnummer ABIN702550

Produktdetails anti-APC Antikörper

Target: APC (Adenomatous Polyposis Coli (APC))

Bindungsspezifität: AA 2751-2843

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser APC Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Kreuzreaktivität: Ratte

Homologie: Human,Mouse,Cow,Pig,Horse,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human APC

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu APC

Target: APC (Adenomatous Polyposis Coli (APC))

Andere Bezeichnung: Adenomatous Polyposis Coli (APC Produkte)

Synonyme: dp2 antikoerper, dp3 antikoerper, fap antikoerper, fpc antikoerper, xapc antikoerper, dp2.5 antikoerper, AI047805 antikoerper, AU020952 antikoerper, AW124434 antikoerper, CC1 antikoerper, Min antikoerper, mAPC antikoerper, BTPS2 antikoerper, DP2 antikoerper, DP2.5 antikoerper, DP3 antikoerper, GS antikoerper, PPP1R46 antikoerper, RATAPC antikoerper, APC1 antikoerper, APC, WNT signaling pathway regulator antikoerper, adenomatous polyposis coli antikoerper, adenomatous polyposis coli protein, putative antikoerper, adenomatosis polyposis coli antikoerper, adenomatous polyposis coli L homeolog antikoerper, APC antikoerper, apc antikoerper, Smp_139190 antikoerper, Apc antikoerper, apc.L antikoerper

Hintergrund:

Synonyms: GS, DP2, DP3, BTPS2, DP2.5, PPP1R46, Adenomatous polyposis coli protein, Protein APC, Deleted in polyposis 2.5, APC

Background: Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization.

Gen-ID: 324

UniProt: P25054

Pathways: WNT Signalweg, Stem Cell Maintenance, Cell-Cell Junction Organization