ARNTL Antikörper (AA 151-250)

Produktnummer ABIN703571

Produktdetails anti-ARNTL Antikörper

Target: ARNTL (Aryl Hydrocarbon Receptor Nuclear Translocator-Like (ARNTL))

Bindungsspezifität: AA 151-250

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ARNTL Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Dog,Cow,Sheep,Pig,Horse

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human BMAL1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu ARNTL

Target: ARNTL (Aryl Hydrocarbon Receptor Nuclear Translocator-Like (ARNTL))

Andere Bezeichnung: BMAL1 (ARNTL Produkte)

Synonyme: BMAL1 antikoerper, BMAL1c antikoerper, JAP3 antikoerper, MOP3 antikoerper, PASD3 antikoerper, TIC antikoerper, bHLHe5 antikoerper, Bmal1 antikoerper, ARNTL antikoerper, xBmal1 antikoerper, arntl antikoerper, Arnt3 antikoerper, BMAL1b antikoerper, bmal1b' antikoerper, aryl hydrocarbon receptor nuclear translocator like antikoerper, aryl hydrocarbon receptor nuclear translocator-like antikoerper, aryl hydrocarbon receptor nuclear translocator like S homeolog antikoerper, ARNTL antikoerper, Arntl antikoerper, arntl.S antikoerper, arntl antikoerper

Hintergrund:

Synonyms: ARNT like protein 1 brain and muscle, ARNTL, Aryl hydrocarbon receptor nuclear translocator like, Aryl hydrocarbon receptor nuclear translocator like protein 1, Aryl hydrocarbon receptor nuclear translocator-like protein 1, Basic helix loop helix PAS orphan MOP3, bHLH PAS protein JAP3, bHLHe5, BMAL 1, BMAL1c, Brain and muscle ARNT like 1, cycle, JAP 3, JAP3, Member of PAS protein 3, Member of PAS superfamily 3, MOP3, PAS domain-containing protein 3, PASD 3, PASD3, TIC.

Background: Component of the circadian clock oscillator which includes the CRY proteins, CLOCK or NPAS2, ARNTL or ARNTL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins. Efficient DNA binding requires dimerization with another bHLH protein. Heterodimerization with CLOCK is required for E-box-dependent transactivation, for CLOCK nuclear translocation and degradation, and, for phosphorylation of both CLOCK and ARNTL. Interaction with PER and CRY proteins requires translocation to the nucleus. Interaction of the CLOCK-ARNTL heterodimer with PER or CRY inhibits transcription activation. Interacts with HSP90, with AHR in vitro, but not in vivo.

Gen-ID: 406

Pathways: Regulation of Lipid Metabolism by PPARalpha, Protein targeting to Nucleus, Warburg Effekt