RAN Antikörper (AA 101-200) (Cy5)

Produktnummer ABIN703590

Produktdetails anti-RAN Antikörper (Cy5)

Target: RAN (RAN, Member RAS Oncogene Family (RAN))

Bindungsspezifität: AA 101-200

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RAN Antikörper ist konjugiert mit Cy5

Applikation: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Kreuzreaktivität: Human

Homologie: Mouse,Rat,Dog,Cow,Pig,Horse,Chicken,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human ARA24

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu RAN

Target: RAN (RAN, Member RAS Oncogene Family (RAN))

Andere Bezeichnung: ARA24 (RAN Produkte)

Synonyme: ARA24 antikoerper, Gsp1 antikoerper, TC4 antikoerper, ran antikoerper, ara24 antikoerper, gsp1 antikoerper, ran-1 antikoerper, tc4 antikoerper, RAN antikoerper, RANP1 antikoerper, AAF30287 antikoerper, CG1404 antikoerper, Dmel\CG1404 antikoerper, Ran antikoerper, dran antikoerper, l(1)G0075 antikoerper, ran10A antikoerper, fc16b04 antikoerper, wu:fc16b04 antikoerper, RAN, member RAS oncogene family antikoerper, RAN, member RAS oncogene family S homeolog antikoerper, CG1404 gene product from transcript CG1404-RC antikoerper, RAN antikoerper, Ran antikoerper, ran.S antikoerper, ran antikoerper

Hintergrund:

Synonyms: Ran, Androgen receptor associated protein 24, ARA 24, ARA24, Gsp1, GTP binding nuclear protein RAN, GTPase Ran, LPS, RAN member RAS oncogene family, Ras like protein TC4, Ras related nuclear protein, RASL2 8, TC 4, TC4, RAN_HUMAN.

Background: Ran (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The Ran protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of Ran requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in Ran disrupt DNA synthesis. Because of its many functions, it is likely that Ran interacts with several other proteins. Ran regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. Ran could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of Ran-GTP around chromatin which, in turn, induces the local nucleation of microtubules. Ran is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). Ran coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease.

Gen-ID: 5901

Pathways: Regulatorische RNA Pathways, Intracellular Steroid Hormone Receptor Signaling Pathway, Protein targeting to Nucleus