Rekombinanter G Protein-Coupled Receptor 119 Antikörper

Produktnummer ABIN7072311

Produktdetails anti-G Protein-Coupled Receptor 119 Antikörper

Target: G Protein-Coupled Receptor 119 (GPR119)

Antikörpertyp: Recombinant Antibody

Reaktivität: Human, Maus, Ratte, Hund

Wirt: Kaninchen

Klonalität: Chimeric

Konjugat: Dieser G Protein-Coupled Receptor 119 Antikörper ist unkonjugiert

Applikation: ELISA, Immunofluorescence (IF), Blocking Peptide (BP)

Verwendungszweck: Anti-Glucose-dependent insulinotropic Receptor [Gipg013], Rabbit IgG, lambda

Spezifität: The original has a Ki value of 7 nM and a Kd value of 6.8 nM for human GIPr.

Kreuzreaktivität: Hund, Maus, Ratte

Produktmerkmale:

Original Species of Ab: Mouse

Original Format of Ab: scFv

Aufreinigung: Protein A affinity purified

Immunogen: Human GIPr.

Klon: Gipg013

Isotyp: IgG lambda

Anwendungsinformationen

Applikationshinweise: This antibody binds to GIPr, a GPCR expressed on pancreatic beta-cells, where activation leads to the release of insulin. Endogeonous ligands for the receptor include oleylethanolamide and lysophosphatidylcholine. The antibody acts as a competitive antagonist. In rat islets, the antibody inhibits GIP-induced secretion of insulin by up to 81 % .

Kommentare:

This full-length, chimeric rabbit antibody was made using the variable domain sequences of the original Mouse scFv format, for improved compatibility with existing reagents, assays and techniques.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Details zu G Protein-Coupled Receptor 119

Target: G Protein-Coupled Receptor 119 (GPR119)

Andere Bezeichnung: Glucose-dependent insulinotropic Receptor (GPR119 Produkte)

Hintergrund: GIPr

UniProt: Q8TDV5

Pathways: Hormone Transport, Peptide Hormone Metabolism