Rekombinanter BACE2 Antikörper

Produktnummer ABIN7072331

Produktdetails anti-BACE2 Antikörper

Target: BACE2 (beta-Site APP-Cleaving Enzyme 2 (BACE2))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser BACE2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Verwendungszweck: Anti-BACE2 [1/ 9 ], Mouse IgG1, kappa

Produktmerkmale:

Original Species of Ab: Mouse

Original Format of Ab: IgG

Aufreinigung: Protein A affinity purified

Immunogen: Human BACE2 244-333.

Klon: 1-9

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: The antibody binds specifically to BACE2, an enzyme responsible for the proteolytic cleavage of amyloid precursor protein (APP). The protein is cleaved between residues 690 and 691, leading to the formation of beta-cleaved soluble APP and a C-terminal membrane bound fragment (CTFβ). The latter is then cleaved by gamma-secretase to generate amyloid beta peptide. BACE is the rate-limiting enzyme in the pathway, and is a potential target in the treatment of Alzheimer's Disease (AD),a neurodegenerative disorder characterised by amyloid beta plaques within the brain. The BACE2 protein is encoded in chromosome 21, in a region critical for the development of Down's Syndrome, and may play a role in the amyloid beta deposition in the disease.

Kommentare:

This reformatted mouse antibody was made using the variable domain sequences of the original Mouse IgG format, for improved compatibility with existing reagents, assays and techniques.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Details zu BACE2

Target: BACE2 (beta-Site APP-Cleaving Enzyme 2 (BACE2))

Andere Bezeichnung: BACE2 (BACE2 Produkte)

Hintergrund: Beta-secretase 2, Aspartic-like protease, Aspartyl protease 1, Asp1, Beta-site amyloid precursor protein cleaving enzyme 2, Down syndrome aspartic protease, DRAP, Memapsin-1, Membrane-associated aspartic protease 1, theta-secretase

UniProt: Q9Y5Z0