Rekombinanter PRNP Antikörper

Produktnummer ABIN7072335

Produktdetails anti-PRNP Antikörper

Target: PRNP (Prion Protein (PRNP))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human, Hamster

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser PRNP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)

Verwendungszweck: Anti-Prion [3F4], Mouse IgG1, kappa

Kreuzreaktivität: Human

Produktmerkmale:

Original Species of Ab: Mouse

Original Format of Ab: IgG2a

Aufreinigung: Protein A affinity purified

Immunogen: Hamster 263K PrPs.

Klon: 3F4

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: The antibody binds specifically to prion, a misfolded protein that has the ability to enter healthy organisms and cause other misfolding of other proteins into their prion form. This plays an essential role in the pathogenesis of certain neurodegenerative disorders such as Creutzfeldt-Jakob disease (CJD), Gerstmann-Staussler syndrome (GSS) and bovine spongiform encephalopathy (BSE). These disorders are characterised by an accumulation of prion proteins in the brain, which have a disrupted secondary structure.

Kommentare:

This reformatted mouse antibody was made using the variable domain sequences of the original Mouse IgG2a format, for improved compatibility with existing reagents, assays and techniques.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Details zu PRNP

Target: PRNP (Prion Protein (PRNP))

Andere Bezeichnung: Prion (PRNP Produkte)

Hintergrund: Major prion protein, p27-30, CD30 antigen, prion protein PrP, prion-related protein

Pathways: Transition Metal Ion Homeostasis, Activated T Cell Proliferation