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Rekombinanter Galanin Antikörper (C-Term)

GAL Reaktivität: Human, Maus WB, ELISA, ICC, BR Wirt: Maus Monoclonal 4B3 unconjugated Recombinant Antibody
Produktnummer ABIN7072341
  • Target Alle Galanin (GAL) Antikörper anzeigen
    Galanin (GAL)
    Antikörpertyp
    Recombinant Antibody
    Bindungsspezifität
    • 8
    • 7
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reaktivität
    • 32
    • 5
    • 5
    • 5
    • 1
    • 1
    Human, Maus
    Wirt
    • 34
    • 4
    • 1
    • 1
    Maus
    Klonalität
    • 37
    • 3
    Monoklonal
    Konjugat
    • 23
    • 7
    • 4
    • 2
    • 2
    • 1
    • 1
    Dieser Galanin Antikörper ist unkonjugiert
    Applikation
    • 25
    • 21
    • 15
    • 14
    • 12
    • 7
    • 6
    • 6
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Blocking Reagent (BR)
    Verwendungszweck
    Anti-Galanin [4B3], Mouse IgG1, kappa
    Spezifität
    The antibody binds to galanin with an affinity constant (Kd) of 0.07 nM reported for the original antibody.
    Kreuzreaktivität
    Maus
    Produktmerkmale

    Original Species of Ab: Mouse

    Original Format of Ab: IgG2a

    Aufreinigung
    Protein A affinity purified
    Immunogen
    C-terminal fusions of KLH to human galanin,
    Klon
    4B3
    Isotyp
    IgG1 kappa
    Top Product
    Discover our top product GAL Primärantikörper
  • Applikationshinweise
    The antibody binds specifically to galanin, a neuropeptide involved in many biological processes, including nociception, modulation and inhibition of action potentials, cognition, feeding, regulation of mood and blood pressure, smooth muscle contraction of the gastrointestinal (GI) tract and insulin release. Galanin acts on three G-protein coupled receptors, GALR1, GALR2 and GALR3, which are highly expressed in the brain, spinal cord and GI tract of humans and other mammals. Activation of the receptors has been reported to activate ATP-sensitive K+ channels, and inhibit voltage-gated Ca2+ channels. Galanin has been associated with the development of cancer, Alzheimer's disease, epilepsy, depression, eating disorders, diabetes and obesity. The monoclonal antibody 4B3 binds to the C-terminal region of Galanin, between residues 21 and 27, blocking its activity, and can be used clinically in the prevention and treatment of diseases mentioned.
    Kommentare

    This reformatted mouse antibody was made using the variable domain sequences of the original Mouse IgG2a format, for improved compatibility with existing reagents, assays and techniques.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1 mg/mL
    Buffer
    PBS with 0.02 % Proclin 300.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
  • Target
    Galanin (GAL)
    Andere Bezeichnung
    Galanin (GAL Produkte)
    Hintergrund
    Gal peptide
    UniProt
    P22466
    Pathways
    Regulation of Hormone Metabolic Process, Feeding Behaviour
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