Rekombinanter CD80 (Galiximab Biosimilar) Antikörper

Produktnummer ABIN7072388

Produktdetails anti-CD80 (Galiximab Biosimilar) Antikörper

Target: CD80 (Galiximab Biosimilar)

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Chimeric

Konjugat: Dieser CD80 (Galiximab Biosimilar) Antikörper ist unkonjugiert

Applikation: Immunoprecipitation (IP), Western Blotting (WB), Blocking Reagent (BR), ELISA, Flow Cytometry (FACS), Immunohistochemistry (IHC)

Verwendungszweck: Anti-CD80 [IDEC-114 (Galiximab)], Rabbit IgG, lambda

Spezifität: Galiximab is a primatized mAb which consists of human constant and primate (cynomolgus macaque) variable regions and binds specifically to CD80. CD80 is a surface glycoprotein and a member of the B7 family of costimulatory molecules. CD80 antigen regulates T cell activation (through interacting with CD28 or CD152) and is expressed transiently in antigen-presenting cells, T cells and normal B cells, and expressed consitutively on various subtypes of B-cell lymphomas.

Produktmerkmale:

Original Species of Ab: Human

Original Format of Ab: IgG1

Aufreinigung: Protein A affinity purified

Immunogen: Galiximab was prepared by immunizing cynomolgus monkeys with recombinant CD80 antigen. The variable regions of the light and heavy chains were then cloned by being incorporated into a cassette vector (N5LG1) containing human constant region genes and subsequently transfected into the Dg44 CHO cell line (Hariharan K, 2013)

Klon: IDEC-114

Isotyp: IgG lambda

Anwendungsinformationen

Applikationshinweise: Galiximab acts to decrease in cell proliferation, inhibition of the constitutively active NF-κB pathway, increase in apoptosis and ADCC against various B-cell lymphoma cell lines. Galiximb affects CD28 and CD152 interactions with CD80. This antibody can also be used for FC, WB, ELISA, IP and IHC.

Kommentare:

This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Details zu CD80 (Galiximab Biosimilar)

Target: CD80 (Galiximab Biosimilar)

Abstract: CD80 (Galiximab Biosimilar) Produkte

Substanzklasse: Biosimilar

Hintergrund: B7-1, T-lymphocyte activation antigen CD80, Activation B7-1 antigen, BB1, CTLA-4 counter-receptor B7.1, B7

UniProt: P33681