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Rekombinanter CD70 Antikörper

CD70 Reaktivität: Maus WB, FACS, IF, BP Wirt: Kaninchen Chimeric TAN1-6 unconjugated Recombinant Antibody
Produktnummer ABIN7072495
  • Target Alle CD70 Antikörper anzeigen
    CD70 (CD70 Molecule (CD70))
    Antikörpertyp
    Recombinant Antibody
    Reaktivität
    • 98
    • 15
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Maus
    Wirt
    • 60
    • 37
    • 8
    • 2
    • 1
    Kaninchen
    Klonalität
    • 61
    • 47
    Chimeric
    Konjugat
    • 53
    • 12
    • 11
    • 9
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser CD70 Antikörper ist unkonjugiert
    Applikation
    • 50
    • 48
    • 44
    • 37
    • 23
    • 19
    • 17
    • 12
    • 11
    • 9
    • 8
    • 7
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF), Blocking Peptide (BP)
    Verwendungszweck
    Anti-CD70 [TAN1-6], Rabbit IgG, kappa
    Spezifität
    This antibody is specific for murine CD70, a 30-33 kDa type II transmembrane glycoprotein. CD70 is a member of the TNF family and is expressed by activated mouse T and B lymphocytes. Interaction of CD70 with CD27, its ligand on T cells, is important in T-B cell crosstalk and plays a role in costimulation and immune regulation.
    Produktmerkmale

    Original Species of Ab: Rat

    Original Format of Ab: IgG2a

    Aufreinigung
    Protein A affinity purified
    Immunogen
    This antibody was raised by immunising LOU rats with soluble recombinant CD70:Fc fusion protein
    Klon
    TAN1-6
    Isotyp
    IgG kappa
    Top Product
    Discover our top product CD70 Primärantikörper
  • Applikationshinweise
    This antibody has been used in various FACS analyses to reveal a critical role for CD70 in CD8 T cell priming by CD40-licensed antigen-presenting cells (Taraban et al, 2004), to demonstrate the differential requirement for CD70 and CD80/CD86 in dendritic cell-mediated activation of tumor-tolerized CD8 T cells (Bak et al, 2012), to examine how temporal changes in dendritic cell subsets, cross-priming and costimulation via CD70 control CD8(+) T cell responses to influenza (Ballesteros-Tato et al, 2010), and to show that CD70 is downregulated by interaction with CD27 (Kuka et al, 2013). In addition, this antibody has been used in vivo to block the CD70-CD27 interaction as part of the two studies examining how CD70 is critically required for the priming of CD8+ T cells (Taraban et al, 2004, Taraban et al, 2006).
    Kommentare

    This chimeric rabbit antibody was made using the variable domain sequences of the original Rat IgG2a format, for improved compatibility with existing reagents, assays and techniques.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1 mg/mL
    Buffer
    PBS with 0.02 % Proclin 300.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
  • Target
    CD70 (CD70 Molecule (CD70))
    Andere Bezeichnung
    CD70 (CD70 Produkte)
    Hintergrund
    TNFSF7, CD27 ligand, CD27-L, Cd27l, CD27LG, CD70 antigen, Ki-24 antigen, Tnfsf7, tumor necrosis factor (ligand) superfamily, member 7, Tumor necrosis factor ligand superfamily member 7
    UniProt
    O55237
    Pathways
    Cancer Immune Checkpoints
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