Rekombinanter CD96 Antikörper

Produktnummer ABIN7072565

Produktdetails anti-CD96 Antikörper

Target: CD96

Antikörpertyp: Recombinant Antibody

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Chimeric

Konjugat: Dieser CD96 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Blocking Peptide (BP)

Verwendungszweck: Anti-CD96 [6A6], Rabbit IgG, lambda

Spezifität: This antibody is specific for murine CD96, and recognises an epitope in the first Ig domain.

Produktmerkmale:

Original Species of Ab: Rat

Original Format of Ab: IgG2a

Aufreinigung: Protein A affinity purified

Immunogen: This antibody was raised by immunising rats with murine CD96.

Klon: 6A6

Isotyp: IgG lambda

Anwendungsinformationen

Applikationshinweise: This antibody blocks murine CD96-CD155 interaction, and has been shown to bind to the first Ig domain of CD96 and compete with CD155 binding (Roman Aguilera et al, 2018). This antibody displays significant anti-metastatic activity in four experimental lung metastases models and one spontaneous tumour metastasis model (Roman Aguilera et al, 2018), with a potency greater than the anti-CD96 monoclonal antibodies 3.3 and 8B10. The binding specificity of this antibody has been determined in flow cytometric analysis of HEK-293 cells transfected with a range of CD96 Ig domain chimeric constructs (Roman Aguilera et al, 2018).

Kommentare:

This chimeric rabbit antibody was made using the variable domain sequences of the original rat IgG2a format, for improved compatibility with existing reagents, assays and techniques.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Details zu CD96

Target: CD96

Andere Bezeichnung: CD96 (CD96 Produkte)

Hintergrund: TACTILE, T-cell surface protein tactile, T cell-activated increased late expression protein

UniProt: Q3U0X8