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Rekombinanter TWEAK Antikörper

TNFSF12 Reaktivität: Maus FACS, BP Wirt: Kaninchen Chimeric MTW-1 unconjugated Recombinant Antibody
Produktnummer ABIN7072583
  • Target Alle TWEAK (TNFSF12) Antikörper anzeigen
    TWEAK (TNFSF12) (Tumor Necrosis Factor (Ligand) Superfamily, Member 12 (TNFSF12))
    Antikörpertyp
    Recombinant Antibody
    Reaktivität
    • 65
    • 26
    • 15
    • 4
    • 2
    • 1
    • 1
    Maus
    Wirt
    • 47
    • 12
    • 10
    • 2
    Kaninchen
    Klonalität
    • 59
    • 12
    Chimeric
    Konjugat
    • 42
    • 10
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser TWEAK Antikörper ist unkonjugiert
    Applikation
    • 43
    • 26
    • 17
    • 13
    • 8
    • 5
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    Flow Cytometry (FACS), Blocking Peptide (BP)
    Verwendungszweck
    Anti-TWEAK [MTW-1], Rabbit IgG, kappa
    Spezifität
    This antibody is specific for murine TWEAK. It has been shown not to react with TNF-α, FasL, and TRAIL.
    Produktmerkmale

    Original Species of Ab: Rat

    Original Format of Ab: IgG1

    Aufreinigung
    Protein A affinity purified
    Immunogen
    This antibody was raised by immunising SD rats with CD8-mTWEAK, a fusion of the human CD8alpha extracellular region to murine TWEAK.
    Klon
    MTW-1
    Isotyp
    IgG kappa
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  • Applikationshinweise
    The specificity of this antibody has been confirmed in flow cytometric analysis, where it reacts specifically with mTWEAK-transfected L5178Y cells, and not with parental L5178Y cells or cells transfected with related TNF family members (Nakayama et al, 2003). Additionally, this antibody has been used to assess TWEAK cell surface expression in flow cytometric analysis (Nakayama et al, 2003). This antibody has been shown to block CD8-mTWEAK cytotoxicity against L5178Y cells over-expressing murine Fn14, the TWEAK receptor (Nakayama et al, 2003). When administered to collagen-induced arthritis (CIA) mice, this blocking antibody has been shown to have anti-inflammatory and antiangiogenic effects, with associated improvements to both the clinical and histological manifestations of CIA (Kamata et al, 2006). Additionally, administration of this antibody to denervated mice attenuates denervation-induced skeletal muscle loss (Mittal et al, 2010). Finally, administration of this antibody to CD163-/- mice subject to hind limb ischaemia inhibits the increased perfusion resulting from CD163 deficiency (Akahori et al, 2015).
    Kommentare

    This chimeric rabbit antibody was made using the variable domain sequences of the original Rat IgG1 format, for improved compatibility with existing reagents, assays and techniques.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1 mg/mL
    Buffer
    PBS with 0.02 % Proclin 300.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
  • Target
    TWEAK (TNFSF12) (Tumor Necrosis Factor (Ligand) Superfamily, Member 12 (TNFSF12))
    Andere Bezeichnung
    TWEAK (TNFSF12 Produkte)
    Hintergrund
    CD255, TNFSF12, TNF-related weak inducer of apoptosis, MTW1, MTW 1, Tumor necrosis factor ligand superfamily member 12,
    UniProt
    O54907
    Pathways
    Apoptose
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