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Rekombinanter L1CAM Antikörper

L1CAM Reaktivität: Human WB, IHC, FACS, IF, IP Wirt: Maus Monoclonal L1-14-10 unconjugated Recombinant Antibody
Produktnummer ABIN7072598
  • Target Alle L1CAM Antikörper anzeigen
    L1CAM (L1 Cell Adhesion Molecule (L1CAM))
    Antikörpertyp
    Recombinant Antibody
    Reaktivität
    • 101
    • 36
    • 31
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 76
    • 28
    • 2
    Maus
    Klonalität
    • 63
    • 42
    • 1
    Monoklonal
    Konjugat
    • 54
    • 11
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser L1CAM Antikörper ist unkonjugiert
    Applikation
    • 52
    • 37
    • 37
    • 25
    • 23
    • 14
    • 13
    • 11
    • 7
    • 7
    • 6
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunofluorescence (IF), Immunoprecipitation (IP)
    Verwendungszweck
    Anti-CD171 [L1-14.10], Mouse IgG1, kappa
    Spezifität
    This antibody is specific for the ectodomain (amino acids M1 to E1123) of human L1, and recognises an epitope in the third Ig domain. L1 is over-expressed in a range of tumours, including neuroblastomas, renal carcinomas, ovarian and endometrial carcinomas, and melanomas. This antibody does not cross-react with human CHL1.
    Produktmerkmale

    Original Species of Ab: Mouse

    Original Format of Ab: IgG1

    Aufreinigung
    Protein A affinity purified
    Immunogen
    This antibody was raised by immunising mice with recombinant L1-Fc fusion protein, consisting of the ectodomain of human L1.
    Klon
    L1-14-10
    Isotyp
    IgG1 kappa
    Top Product
    Discover our top product L1CAM Primärantikörper
  • Applikationshinweise
    The specificity of this antibody has been confirmed in flow cytometric (Schafer et al, 2012, Huszar et al, 2006) and Western blot analysis (Huszar et al, 2006, Wolterink et al, 2010). This antibody has been shown, when incubated with SKOV3ip human ovarian carcinoma cells, to efficiently and sustainedly block extracellular signal-regulated kinase (Erk) phosphorylation (Gast et al, 2008). This antibody has been used in immunohistochemical staining for L1 expression, using paraffin-embedded human ovarian carcinoma tissue sections (Wolterink et al, 2010, Knogler et al, 2007) and a panel of human tumour tissue sections, including benign and malignant tumours of the female genital tract (Huszar et al, 2006), and renal cell carcinoma, schwannoma, gastric conventional GIST, pancreatic neuroendocrine tumor and paraganglioma (Inaguma et al, 2016). This antibody, when administered to SCID mice in combination with cytostatic drugs, efficiently reduces the growth of subcutaneously grown Colo357 or SKOV3ip tumors (Schafer et al, 2012).
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1 mg/mL
    Buffer
    PBS with 0.02 % Proclin 300.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
  • Target
    L1CAM (L1 Cell Adhesion Molecule (L1CAM))
    Andere Bezeichnung
    CD171 (L1CAM Produkte)
    Hintergrund
    L1CAM, 14.10, L1, Neural cell adhesion molecule L1, N-CAM-L1, NCAM-L1
    UniProt
    P32004
    Pathways
    Synaptic Membrane
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