Rekombinanter IL-10RA Antikörper (Extracellular Domain)
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- Target Alle IL-10RA (IL10RA) Antikörper anzeigen
- IL-10RA (IL10RA) (Interleukin 10 Receptor, alpha (IL10RA))
- Antikörpertyp
- Recombinant Antibody
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Bindungsspezifität
- Extracellular Domain
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Reaktivität
- Maus
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Wirt
- Kaninchen
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Klonalität
- Chimeric
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Konjugat
- Dieser IL-10RA Antikörper ist unkonjugiert
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Applikation
- Flow Cytometry (FACS), Blocking Peptide (BP)
- Verwendungszweck
- Anti-IL-10R [1B1.3a], Rabbit IgG, kappa
- Spezifität
- This antibody recognises mouse IL-10R which is a cell surface glycoprotein and a receprot for anti-inflammatory IL-10. The epitope recognised by this antibody has been localised to the ligand binding domain within the extracellular region of mouse IL-10R.
- Produktmerkmale
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Original Species of Ab: Rat
Original Format of Ab: IgG1
- Aufreinigung
- Protein A affinity purified
- Immunogen
- This antibody was raised by immunising rats with the purified recombinant extracellular region of mouse Interleukin 10 Receptor.
- Klon
- 1B1-3a
- Isotyp
- IgG kappa
- Top Product
- Discover our top product IL10RA Primärantikörper
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- Applikationshinweise
- 1B1.3a has been widely applied in flow cytometric analyses where the detection of IL-10R was needed. Furthermore, this antibody was also successfully utilised as a blocking agent, one group used it to demonstrate that IL-10 mediates suppressive activity, by targeting its receptor IL-10R with this antibody (Wang et al., 2004). Castro et al. (2000) demonstrated that 1B1.3a is able to make a soluble peptide or protein antigen immunogenic for subsequent Th1 recall responses in a situation when there is an additional signal, such as LPS, activating the immune system. Consequently, this antibody is a hugely promising agent in the potential development of vaccines for immunotherapy. Similarly, Vicari and colleagues (2002) showed that this antibody has an enormous potential as a therapeutic anti-tumour agent when combined with the administration of CpG to stimulate the immune system.
- Kommentare
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This chimeric rabbit antibody was made using the variable domain sequences of the original Rat IgG1 format, for improved compatibility with existing reagents, assays and techniques.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 1 mg/mL
- Buffer
- PBS with 0.02 % Proclin 300.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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- Target
- IL-10RA (IL10RA) (Interleukin 10 Receptor, alpha (IL10RA))
- Andere Bezeichnung
- IL-10R (IL10RA Produkte)
- Hintergrund
- CD210, Interleukin-10 receptor subunit, Interleukin-10 receptor subunit alpha, Il10ra Il10r, IL-10 receptor subunit alpha, IL-10R subunit alpha, IL-10RA, CDw210a, Interleukin-10 receptor subunit 1, IL-10R subunit 1, IL-10R1, IBI-3A, 1B1-3A
- UniProt
- Q61727
- Pathways
- Growth Factor Binding
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