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Rekombinanter IL-10RA Antikörper (Extracellular Domain)

IL10RA Reaktivität: Maus FACS, BP Wirt: Kaninchen Chimeric 1B1-3a unconjugated Recombinant Antibody
Produktnummer ABIN7072606
  • Target Alle IL-10RA (IL10RA) Antikörper anzeigen
    IL-10RA (IL10RA) (Interleukin 10 Receptor, alpha (IL10RA))
    Antikörpertyp
    Recombinant Antibody
    Bindungsspezifität
    • 10
    • 9
    • 7
    • 6
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Extracellular Domain
    Reaktivität
    • 79
    • 43
    • 19
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    Maus
    Wirt
    • 69
    • 20
    • 10
    • 2
    Kaninchen
    Klonalität
    • 70
    • 30
    Chimeric
    Konjugat
    • 58
    • 9
    • 5
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser IL-10RA Antikörper ist unkonjugiert
    Applikation
    • 67
    • 32
    • 22
    • 15
    • 14
    • 7
    • 5
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Blocking Peptide (BP)
    Verwendungszweck
    Anti-IL-10R [1B1.3a], Rabbit IgG, kappa
    Spezifität
    This antibody recognises mouse IL-10R which is a cell surface glycoprotein and a receprot for anti-inflammatory IL-10. The epitope recognised by this antibody has been localised to the ligand binding domain within the extracellular region of mouse IL-10R.
    Produktmerkmale

    Original Species of Ab: Rat

    Original Format of Ab: IgG1

    Aufreinigung
    Protein A affinity purified
    Immunogen
    This antibody was raised by immunising rats with the purified recombinant extracellular region of mouse Interleukin 10 Receptor.
    Klon
    1B1-3a
    Isotyp
    IgG kappa
    Top Product
    Discover our top product IL10RA Primärantikörper
  • Applikationshinweise
    1B1.3a has been widely applied in flow cytometric analyses where the detection of IL-10R was needed. Furthermore, this antibody was also successfully utilised as a blocking agent, one group used it to demonstrate that IL-10 mediates suppressive activity, by targeting its receptor IL-10R with this antibody (Wang et al., 2004). Castro et al. (2000) demonstrated that 1B1.3a is able to make a soluble peptide or protein antigen immunogenic for subsequent Th1 recall responses in a situation when there is an additional signal, such as LPS, activating the immune system. Consequently, this antibody is a hugely promising agent in the potential development of vaccines for immunotherapy. Similarly, Vicari and colleagues (2002) showed that this antibody has an enormous potential as a therapeutic anti-tumour agent when combined with the administration of CpG to stimulate the immune system.
    Kommentare

    This chimeric rabbit antibody was made using the variable domain sequences of the original Rat IgG1 format, for improved compatibility with existing reagents, assays and techniques.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1 mg/mL
    Buffer
    PBS with 0.02 % Proclin 300.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
  • Target
    IL-10RA (IL10RA) (Interleukin 10 Receptor, alpha (IL10RA))
    Andere Bezeichnung
    IL-10R (IL10RA Produkte)
    Hintergrund
    CD210, Interleukin-10 receptor subunit, Interleukin-10 receptor subunit alpha, Il10ra Il10r, IL-10 receptor subunit alpha, IL-10R subunit alpha, IL-10RA, CDw210a, Interleukin-10 receptor subunit 1, IL-10R subunit 1, IL-10R1, IBI-3A, 1B1-3A
    UniProt
    Q61727
    Pathways
    Growth Factor Binding
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