BPTF Antikörper

Produktnummer ABIN7073234

Produktdetails anti-BPTF Antikörper

Target: BPTF (Bromodomain PHD Finger Transcription Factor (BPTF))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BPTF Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Immunofluorescence (IF)

Kreuzreaktivität: Maus, Ratte

Aufreinigung: Affinity purification

Immunogen: Recombinant protein corresponding to Human BPTF

Anwendungsinformationen

Applikationshinweise: IHC/IF (H,M,R) 1:500-1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS, pH 7.4, 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Details zu BPTF

Target: BPTF (Bromodomain PHD Finger Transcription Factor (BPTF))

Andere Bezeichnung: BPTF/FALZ (BPTF Produkte)

Synonyme: FAC1 antikoerper, FALZ antikoerper, NURF301 antikoerper, 9430093H17Rik antikoerper, Falz antikoerper, BPTF antikoerper, bromodomain PHD finger transcription factor antikoerper, nucleosome-remodeling factor subunit NURF301 antikoerper, fetal alzheimer antigen, falz antikoerper, BPTF antikoerper, Bptf antikoerper, LOC5576547 antikoerper, CpipJ_CPIJ011285 antikoerper, bptf antikoerper

Hintergrund: FALZ/BPTF is a histone-binding component of NURF (nucleosome remodeling factor), a complex that catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. This gene was identified in brain homogenates from patients with Alzheimer's disease. Analysis of the original protein (fetal Alz-50 reactive clone 1, or FAC1), containing a DNA-binding domain, a zinc finger motif, and a C-terminal bromodomain, suggested it might play a role in the regulation of transcription during proliferation. High levels of FAC1 were detected in fetal brain and in patients with neurodegenerative diseases. This protein is highly similar to the largest subunit of the Drosophila NURF (nucleosome remodeling factor) complex. In Drosophila, the NURF complex, which catalyzes nucleosome sliding on DNA and interacts with sequence-specific transcription factors, is necessary for the chromatin remodeling required for transcription.

Gen-ID: 2186

NCBI Accession: NP_004450

UniProt: Q12830