CSN2 Antikörper
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- Target Alle CSN2 Antikörper anzeigen
- CSN2 (Casein beta (CSN2))
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Reaktivität
- Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser CSN2 Antikörper ist unkonjugiert
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Applikation
- Immunohistochemistry (IHC), Immunofluorescence (IF)
- Kreuzreaktivität
- Ratte
- Aufreinigung
- Affinity purification
- Immunogen
- Recombinant protein corresponding to Mouse CSN2
- Top Product
- Discover our top product CSN2 Primärantikörper
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- Applikationshinweise
- IHC/IF (M,R) 1:700-1:1400
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
- PBS, pH 7.4, 0.02 % sodium azide
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
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- Target
- CSN2 (Casein beta (CSN2))
- Andere Bezeichnung
- CSN2 (CSN2 Produkte)
- Synonyme
- CASB antikoerper, Csnb antikoerper, casein beta antikoerper, CSN2 antikoerper, Csn2 antikoerper
- Hintergrund
- COPS2 is an essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
- Gen-ID
- 12848
- NCBI Accession
- NP_001272441
- UniProt
- P61202
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