CUBN Antikörper

Produktnummer ABIN7073601

Produktdetails anti-CUBN Antikörper

Target: CUBN (Cubilin (Intrinsic Factor-Cobalamin Receptor) (CUBN))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CUBN Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Kreuzreaktivität: Human, Ratte

Aufreinigung: Affinity purification

Immunogen: Recombinant protein corresponding to Mouse Cubilin

Anwendungsinformationen

Applikationshinweise: WB (M,R) 1:500-1:1000, IHC/IF (H,M,R) 1:650-1:1300

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS, pH 7.4, 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Details zu CUBN

Target: CUBN (Cubilin (Intrinsic Factor-Cobalamin Receptor) (CUBN))

Andere Bezeichnung: Cubilin (CUBN Produkte)

Synonyme: GP280 antikoerper, IFCR antikoerper, MGA1 antikoerper, AA408369 antikoerper, AL022750 antikoerper, D2Wsu88e antikoerper, gp280 antikoerper, cubilin antikoerper, cubilin (intrinsic factor-cobalamin receptor) antikoerper, LOC411053 antikoerper, CUBN antikoerper, cubn antikoerper, Cubn antikoerper

Hintergrund: Cubilin is an endocytic receptor that lacks a classical transmembrane region. It is a multidomain receptor that contains an amino terminal 110 residue segment followed by 8 epidermal growth factor (EGF)-like repeats and a contiguous stretch of 27 CUB domains. Cubilin acts as a receptor for intrinsic factor-vitamin B12 complexes. Cubilin is located within the epithelium of intestine and kidney. Mutations in Cubilin may play a role in autosomal recessive megaloblastic anemia also known as Imerslund-Grasbeck's disease, which causes intestinal malabsorption of vitamin B12.

Molekulargewicht: 399 kDa

Gen-ID: 65969

NCBI Accession: NP_001074553

UniProt: Q9JLB4

Pathways: Metabolism of Steroid Hormones and Vitamin D, Lipid Metabolism