EIF2AK1 Antikörper
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- Target Alle EIF2AK1 Antikörper anzeigen
- EIF2AK1 (Eukaryotic Translation Initiation Factor 2-alpha Kinase 1 (EIF2AK1))
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Reaktivität
- Human, Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser EIF2AK1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
- Kreuzreaktivität
- Human, Ratte
- Aufreinigung
- Affinity purification
- Immunogen
- Recombinant protein corresponding to Mouse Heme-regulated inhibitor
- Top Product
- Discover our top product EIF2AK1 Primärantikörper
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- Applikationshinweise
- WB (H,M,R) 1 :500-1: 1000, IHC/IF (M,R) 1:800-1:1600/1:500-1:1000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
- PBS, pH 7.4, 0.02 % sodium azide
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
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- Target
- EIF2AK1 (Eukaryotic Translation Initiation Factor 2-alpha Kinase 1 (EIF2AK1))
- Andere Bezeichnung
- Heme-regulated inhibitor (EIF2AK1 Produkte)
- Synonyme
- HCR antikoerper, Hri antikoerper, HRI antikoerper, wu:fj97h09 antikoerper, zgc:153232 antikoerper, eukaryotic translation initiation factor 2 alpha kinase 1 antikoerper, eukaryotic translation initiation factor 2-alpha kinase 1 antikoerper, eukaryotic translation initiation factor 2 alpha kinase 1 L homeolog antikoerper, EIF2AK1 antikoerper, eif2ak1 antikoerper, Eif2ak1 antikoerper, eif2ak1.L antikoerper
- Hintergrund
- The Eif2ak1 Inhibits protein synthesis at the translation initiation level, in response to various stress conditions, including oxidative stress, heme deficiency, osmotic shock and heat shock. Exerts its function through the phosphorylation of EIF2S1 at 'Ser-48' and 'Ser-51', thus preventing its recycling. Binds hemin forming a 1:1 complex through a cysteine thiolate and histidine nitrogenous coordination. This binding occurs with moderate affinity, allowing it to sense the heme concentration within the cell. Thanks to this unique heme-sensing capacity, plays a crucial role to shut off protein synthesis during acute heme-deficient conditions. In red blood cells, controls hemoglobin synthesis ensuring a coordinated regulation of the synthesis of its heme and globin moieties.
- Molekulargewicht
- 70 kDa
- Gen-ID
- 15467
- NCBI Accession
- NP_038585
- UniProt
- Q9Z2R9
- Pathways
- Hepatitis C
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