GBA Antikörper

Produktnummer ABIN7074062

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch GBA in IHC und IF. Er zeigt eine Reaktivität gegenüber Maus und Ratte.

Kurzübersicht für GBA Antikörper (ABIN7074062)

Target: GBA (Glucosidase, Beta, Acid (GBA))

Reaktivität: Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GBA Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-GBA Antikörper

Kreuzreaktivität: Ratte

Aufreinigung: Affinity purification

Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse GBA

Anwendungsinformationen

Applikationshinweise: IHC/IF (M,R) 1:1000-1:2000/1:500-1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS, pH 7.4, 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Details zu GBA

Target: GBA (Glucosidase, Beta, Acid (GBA))

Andere Bezeichnung: GBA

Hintergrund: The GBA is a glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose. Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes . Through the production of ceramides, participates to the PKC-activated salvage pathway of ceramide formation. Also plays a role in cholesterol metabolism . May either catalyze the glucosylation of cholesterol, through a transglucosylation reaction that transfers glucose from glucosylceramide to cholesterol . The short chain saturated C8:0-GlcCer and the mono-unsaturated C18:0-GlcCer being the most effective glucose donors for that transglucosylation reaction. Under specific conditions, may alternatively catalyze the reverse reaction, transferring glucose from cholesteryl-beta-D-glucoside to ceramide. Finally, may also hydrolyze cholesteryl-beta-D-glucoside to produce D-glucose and cholesterol .

Gen-ID: 14466

NCBI Accession: NP_001070879

UniProt: P17439

Pathways: Cellular Glucan Metabolic Process