Presenilin 2 Antikörper (AA 51-150)

Produktnummer ABIN704516

Produktdetails anti-Presenilin 2 Antikörper

Target: Presenilin 2 (PSEN2) (Presenilin 2 (Alzheimer Disease 4) (PSEN2))

Bindungsspezifität: AA 51-150

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Presenilin 2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human presenilin 2/PS-2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu Presenilin 2

Target: Presenilin 2 (PSEN2) (Presenilin 2 (Alzheimer Disease 4) (PSEN2))

Andere Bezeichnung: presenilin 2/PS-2 (PSEN2 Produkte)

Synonyme: AD3L antikoerper, AD4 antikoerper, CMD1V antikoerper, PS2 antikoerper, STM2 antikoerper, ALG-3 antikoerper, Ad4h antikoerper, Alg3 antikoerper, PS-2 antikoerper, Psnl2 antikoerper, pre2 antikoerper, zf-PS2 antikoerper, PSNL2 antikoerper, PSEN2 antikoerper, ad4 antikoerper, ps2 antikoerper, ad3l antikoerper, stm2 antikoerper, Ps2 antikoerper, presenilin 2 antikoerper, presenilin 2 S homeolog antikoerper, presenilin 2 (Alzheimer disease 4) antikoerper, trefoil factor 1 antikoerper, PSEN2 antikoerper, Psen2 antikoerper, psen2 antikoerper, psen2.S antikoerper, Tff1 antikoerper

Hintergrund:

Synonyms: AD 3L, AD 3LP, AD 4, AD 5, AD3L, AD3LP, AD4, AD5, Alzheimer disease 4, Alzheimer disease familial type 4, E5 1, Presenilin2, Presenilin 2, Presenilin 2, PS 2, PS2, PSEN 2, PSNL 2, PSNL2, STM 2, STM2.

Background: Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1, PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Two alternative transcripts of PSEN2 have been identified.

Gen-ID: 5664

Pathways: Notch Signalweg, EGFR Signaling Pathway, Neurotrophin Signalübertragung