im:680590 antikoerper, lrp2 antikoerper, dbs antikoerper, gp330 antikoerper, megalin antikoerper, DBS antikoerper, GP330 antikoerper, AI315343 antikoerper, AW536255 antikoerper, D230004K18Rik antikoerper, Gp330 antikoerper, Megalin antikoerper, LDL receptor related protein 2 antikoerper, low density lipoprotein receptor-related protein 2a antikoerper, low density lipoprotein receptor-related protein 2 antikoerper, low-density lipoprotein receptor-related protein 2 antikoerper, LDL receptor related protein 2 L homeolog antikoerper, LRP2 antikoerper, lrp2a antikoerper, LRP2.3 antikoerper, lrp2.L antikoerper, LOC100183506 antikoerper, lrp2 antikoerper, Lrp2 antikoerper
Hintergrund
The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones.