PP4R2 antikoerper, BE691708 antikoerper, C230060M08Rik antikoerper, ppp4r2 antikoerper, fe11b04 antikoerper, wu:fe11b04 antikoerper, ppp4r2-B antikoerper, wu:fa17h08 antikoerper, wu:fc23g05 antikoerper, protein phosphatase 4 regulatory subunit 2 antikoerper, protein phosphatase 4, regulatory subunit 2 antikoerper, protein phosphatase 4, regulatory subunit 2a antikoerper, protein phosphatase 4 regulatory subunit 2 S homeolog antikoerper, protein phosphatase 4 regulatory subunit 2 L homeolog antikoerper, protein phosphatase 4, regulatory subunit 2b antikoerper, PPP4R2 antikoerper, Ppp4r2 antikoerper, ppp4r2a antikoerper, ppp4r2.S antikoerper, ppp4r2 antikoerper, ppp4r2.L antikoerper, ppp4r2b antikoerper
Hintergrund
Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair.