KDM3B Antikörper (AA 1601-1761)

Produktnummer ABIN704651

Produktdetails anti-KDM3B Antikörper

Target: KDM3B (Lysine (K)-Specific Demethylase 3B (KDM3B))

Bindungsspezifität: AA 1601-1761

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KDM3B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Dog,Cow,Pig,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human JMJD1B

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu KDM3B

Target: KDM3B (Lysine (K)-Specific Demethylase 3B (KDM3B))

Andere Bezeichnung: JMJD1B (KDM3B Produkte)

Synonyme: KDM3B antikoerper, JMJD1B antikoerper, 5830462I21Rik antikoerper, JHDM2B antikoerper, Jmjd1b antikoerper, mKIAA1082 antikoerper, 5qNCA antikoerper, C5orf7 antikoerper, NET22 antikoerper, lysine demethylase 3B antikoerper, lysine (K)-specific demethylase 3B antikoerper, lysine-specific demethylase 3B antikoerper, KDM3B lysine (K)-specific demethylase 3B antikoerper, KDM3B antikoerper, LOC100540242 antikoerper, kdm3b antikoerper, Kdm3b antikoerper

Hintergrund:

Synonyms: JHDM2B, JmjC domain containing histone demethylation protein 2B, JmjC domain-containing histone demethylation protein 2B , jmjd1b, Jumonji domain containing protein 1B, JUMONJI DOMAIN-CONTAINING PROTEIN 1B , KDM3B, KDM3B_HUMAN, Lysine-specic demethylase 3B, Nuclear protein 5qNCA.

Background: JMJD1B (jumonji domain containing 1B), also known as KDM3B, 5qNCA (5q Nuclear Co-Activator) or C5orf7, is a member of the JHDM2 histone demethylase family of proteins. Expressed in a wide variety of tissues, JMJD1B localizes to the nucleus and contains one JMJC domain and a C-terminal zinc finger motif. JMJD1B functions as a histone demethylase and, using iron as a cofactor, demethylates lysine-9 of Histone H3. This suggests that JMJD1B plays a central role in the histone code. The gene encoding human JMJD1B is located within the 5q region of the genome that is often deleted in myeloid leukemias and myelodysplasias. This implies that JMJD1B may function as a tumor suppressor of myeloid leukemia. Eptopic expression of JMJD1B exhibits growth suppressive activities, further supporting a role for JMJD1B in tumor suppression.

Gen-ID: 51780

Pathways: Warburg Effekt