TBC1D7 Antikörper
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- Target Alle TBC1D7 Antikörper anzeigen
- TBC1D7 (TBC1 Domain Family, Member 7 (TBC1D7))
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Reaktivität
- Human, Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser TBC1D7 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Kreuzreaktivität
- Human, Ratte
- Aufreinigung
- Affinity purification
- Immunogen
- Recombinant protein corresponding to Mouse TBC1D7
- Top Product
- Discover our top product TBC1D7 Primärantikörper
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- Applikationshinweise
- WB (H,M,R) 1: 500- 1: 1000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
- PBS, pH 7.4, 0.02 % sodium azide
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
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- Target
- TBC1D7 (TBC1 Domain Family, Member 7 (TBC1D7))
- Andere Bezeichnung
- TBC1D7 (TBC1D7 Produkte)
- Synonyme
- PIG51 antikoerper, TBC7 antikoerper, dJ257A7.3 antikoerper, 2610009C09Rik antikoerper, TBC1 domain family member 7 antikoerper, TBC1 domain family, member 7 antikoerper, TBC1D7 antikoerper, Tbc1d7 antikoerper
- Hintergrund
- TBC1 domain family member 7 (TBC1D7, TBC7) belongs to a family of TBC (Tre-2/Bub2/Cdc16) containing proteins that function as GTPase-activating proteins (GAPs) . TBC1D7 was initially identified as a novel binding protein within the TSC1-TSC2 complex, where it was thought to associate with TSC1 . Additional research indicates that TBC1D7 is a third subunit of the TSC1-TSC2 complex that possesses Rheb-GAP activity and signals upstream of mTORC1. Knockdown of TBC1D7 limits the association between TSC1 and TSC2, resulting in reduced Rheb-GAP activity and increased mTORC1 signaling . Mutations in the corresponding TBC1D7 gene result in increased mTORC1 signaling, delayed autophagy, and are associated with intellectual disability (ID) and macrocrania.
- Molekulargewicht
- 36 kDa
- Gen-ID
- 67046
- NCBI Accession
- NP_001239568
- UniProt
- Q9D0K0
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