ZNF746 Antikörper

Produktnummer ABIN7076272

Produktdetails anti-ZNF746 Antikörper

Target: ZNF746 (Zinc Finger Protein 746 (ZNF746))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ZNF746 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Kreuzreaktivität: Human, Ratte

Aufreinigung: Affinity purification

Immunogen: Recombinant protein corresponding to Mouse PARIS

Anwendungsinformationen

Applikationshinweise: WB (H) 1:500-1:1000, IHC/IF (M,R) 1:1500-1:3000/1:1500-1:3000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS, pH 7.4, 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Details zu ZNF746

Target: ZNF746 (Zinc Finger Protein 746 (ZNF746))

Andere Bezeichnung: PARIS (ZNF746 Produkte)

Hintergrund: ZNF746, also named as PARIS, which belongs to the krueppel C2H2-type zinc-finger protein family. ZNF746 mainly localizes to the cytoplasm and probably translocates to the nucleus to repress selected genes. ZNF746 as a transcription repressor that specifically binds to the 5'-TATTTT[T/G]-3' consensus sequence on promoters and repress transcription of PGC-1-alpha (PPARGC1A), thereby playing a role in regulation of neuron death. ZNF746 may act as a downstream effector of PRKN and contribute to neurodegeneration in Parkinson disease cases caused by defects in PRKN.

Molekulargewicht: 100 kDa

Gen-ID: 69228

NCBI Accession: NP_001156947

UniProt: Q3U133