B330005D23Rik antikoerper, FOG-2 antikoerper, FOG2 antikoerper, DIH3 antikoerper, ZC2HC11B antikoerper, ZNF89B antikoerper, hFOG-2 antikoerper, FOG-A antikoerper, fog2a antikoerper, zgc:152696 antikoerper, zinc finger protein, multitype 2 antikoerper, zinc finger protein, FOG family member 2 antikoerper, zinc finger protein, FOG family member 2a antikoerper, Zfpm2 antikoerper, ZFPM2 antikoerper, zfpm2a antikoerper
Hintergrund
FOG-2 is the transcriptional cofactors of FOG family . FOG-2 is able to both positively and negatively influence GATA mediated transcription. FOG-2 is predominantly expressed in heart, neurons and gonads, and it preferentially participates in the regulation of GATA-3, GATA-4 and GATA-6. In cardiomyocytes and fibroblasts, FOG-2 inhibits GATA-4 transcriptional activity, yet FOG-2 restores GATA-1 mediated transcription in erythroid cultures deficient in FOG, suggesting that the observed effects of FOG-2 are context specific and vary between cellular systems.