CD74 Antikörper (FITC)

Produktnummer ABIN7076707

Produktdetails anti-CD74 Antikörper (FITC)

Target: CD74 (HLA-DR-gamma (CD74))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD74 Antikörper ist konjugiert mit FITC

Applikation: Flow Cytometry (FACS)

Verwendungszweck: CD74 FITC Antibody

Produktmerkmale: PIN.1 recognizes a ~33-35 kDa protein doublet, corresponding to the apparent molecular mass of the p33 and p35 forms of the cytoplasmic tail of human CD74, a type II transmembrane glycoprotein. It is also known as invariant chain or MHC class II chaperone or MIF (macrophage migration inhibitory factor) receptor. It plays a critical role in the antigen processing leading to antigen presentation by MHC class II to CD4+ T cells. Antigen presenting cells such as B cells, monocytes/macrophages, dendritic cells, and Langerhans cells as well as activated T, carcinomas of lung, renal, gastric and thymic origins express CD74. The CD44 is an integral member of CD74 receptor complex and required for the CD74 signal transduction. CD74's cytoplasmic domain binds chromatin and regulates transcription and expression of genes involved in immune regulation, cell survival, and hematopoietic cancers. Published report claimed that the urease B subunit released by H. pylori binds to CD74 of gastric epithelial cells leading to induce NF-κB activation and IL-8 production.

Aufreinigung: Purified

Reinheit: >95 %

Güteklasse: GMP Grade

Immunogen: An EBV-transformed B cell line from a patient with MHC class II deficiency

Klon: PIN-1

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: FC: 5 µL/test We recommend that every lab carries out an initial titration study before running your samples to ensure that the optimal concentration is selected for your application.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS, pH 7.2, 0.09 % Sodium azide and 0.2 % (w/v) BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: 2-8°C, Conjugated antibodies should never be frozen.

Details zu CD74

Target: CD74 (HLA-DR-gamma (CD74))

Andere Bezeichnung: CD74 (CD74 Produkte)

Gen-ID: 972

UniProt: P04233

Pathways: Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Negative Regulation of intrinsic apoptotic Signaling, Cancer Immune Checkpoints